Institute of Innovative Research, 
Tokyo Institute of Technology.


Press Release

New Study Finds Novel functions of the Pyruvate-Sensing Protein PdhR in E. coli

Scientists at Meiji University, Hosei University, and Tokyo Institute of Technology (Tokyo Tech) aimed to better understand the homeostasis of pyruvate, a key connection point of many metabolic pathways in Escherichia coli bacteria. Scientists focused on a transcription factor called PdhR because it regulates pyruvate breakdown into other molecules. They identified ~20 genes that PdhR targets, and showed their involvement in pathways connected to pyruvate.