Institute of Innovative Research, 
Tokyo Institute of Technology.


Press Release

Steric Zipper Interactions in Artificial Crystalline Peptide β-Sheets

A novel approach to constructing crystalline artificial steric zippers has been reported by scientists at Tokyo Tech. Such structures contribute to the extraordinary stability of amyloid fibrils associated with neurodegenerative diseases. By folding and assembling tetrapeptide fragments using metal ions, the scientists observed two classes of steric zippers. Their insights into the structural features of steric zippers hold promise for the development of artificial peptide materials.