Institute of Innovative Research, 
Tokyo Institute of Technology.


Press Release

Unraveling the Molecular Basis of Dmc1 Filament Assembly in Homologous Recombination

Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1-driven homologous recombination by acting on different steps during filament assembly, reveal Tokyo Tech researchers in collaboration with National Taiwan University. Using two types of single-molecule experiments, the researchers studied the role of these accessory proteins in Dmc1 filament assembly in fission yeast. Their findings provide a molecular basis for the stimulation mechanism involved in recombination events, and open doors to a deeper understanding of the processes underlying meiosis.