2023.02.06
“Snapshots” of Translation Could Help Us Investigate Cellular Proteins
Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption. This method, developed by scientists at Tokyo Tech, allows for the large-scale harvesting, processing, and identification of pep-tRNA polypeptide moieties.
