Nascent Polypeptides Stabilize Ribosomes for Uninterrupted Translation, Tokyo Tech Scientists Show
Protein production (translation) is a complex process involving machinery called ribosomes. How do cells counter ribosomal destabilization leading to premature termination of translation? Scientists at Tokyo Institute of Technology (Tokyo Tech) uncover a novel role of nascent protein chains in stabilizing translating ribosomes. They suggest that longer peptide sequences spanning the ribosomal exit tunnel and bulky amino acid residues in the tunnel entry help stabilize the ribosome by bridging its subunits, ensuring uninterrupted translation.