Institute of Innovative Research, 
Tokyo Institute of Technology.


Press Release

Selective mRNA Degradation via Autophagy: A Novel Role for Autophagy in Gene Regulation

Scientists at the Tokyo Institute of Technology (Tokyo Tech) have discovered that autophagy plays a key role in messenger RNA (mRNA) degradation. Using yeast as a model system, they have demonstrated that autophagy-mediated mRNA degradation is not a random event but rather a selective one, wherein specific mRNAs are targeted for degradation. Interestingly, this process is tightly coupled with ribosomal association. The researchers have therefore uncovered a novel function of autophagy in gene regulation.