Scientists unraveling the molecular details of DNA recombination regulation
An international team from National Taiwan University (NTU) and Tokyo Tech identified how DNA recombinational repair is regulated in a recent work published in Proceedings of the National Academy of Sciences of the United States of America (PNAS). To repair damaged DNA, recombinases bind to DNA in order to initiate the repair work. However, the recombinase-DNA complex must be sufficiently stable to carry out the work. Scientists from NTU and Tokyo Tech work together to identify how another protein helps to stabilize this recombinase-DNA complex to efficiently proceed to proper DNA repair.